Mayor Andy Burnham said the redevelopment of the Old Trafford area would make Manchester arguably the biggest city in world football.
A taskforce, including Burnham, was announced this week to consider options for Old Trafford's future.
United are hoping to repeat the regeneration that Manchester's east side has experienced since City moved to the Etihad Stadium in 2003.
Burnham says there is “no other city that comes close” to Manchester.
“You could argue that this is the biggest city in world football.” 1710005454 Because we've got two clubs in there,” Burnham told BBC Sport's Simon Stone.
“There is no doubt that if an ambitious vision is realized, whether it is a renovation or new construction.”
The special committee will deliberately not include club officials and will be led by Lord Coe.
The club's co-owner Sir Jim Ratcliffe has announced his intention to build a completely new stadium next to Manchester United's current Old Trafford Stadium, and council leaders have announced plans to build an entirely new stadium next to Manchester United's current Old Trafford Stadium. He welcomes the club's plans to regenerate.
The task force is expected to make its recommendations in late 2024, but Burnham believes either option, a new stadium or redevelopment, will enable Manchester to become the center of world football.
“Manchester City is at the center of a new campus of facilities on the west side of Greater Manchester, linked to Media City.Manchester City will be building a large new indoor arena from Etihad Airways I continue to do that. If you go there, think about that,” Burnham added.
“When it comes to football infrastructure, there is no other city in the world that can match Manchester, no one can match it, which is why I will support this task force to the fullest. Because the benefits to our city regions are: “Once we unlock it, it's going to be huge.'' It's not a pretense. ”
As part of Mr Ratcliffe's desire to build a new stadium and regenerate the area, the 71-year-old said the club would be in “discussions” with the government about funding.
“It's too early [to discuss funding]we’re not even there,” Burnham added.
“What I will have to do over the next five or six months as part of the select committee, working with Lord Coe and Gary. [Neville] Do you provide all the other supporting information to make a decision? Renovated or new construction?
“In either case, there is a large freight depot directly behind the station and Old Trafford so public funding will need to be involved and this is also an issue and needs to be considered.
“We are talking about a complex regeneration plan that could be the biggest in our lifetime in the north of England, so why wouldn’t I want that as Mayor of Greater Manchester?
“To be honest, the more ambitious the club is, the better it is for us, because then the benefits will trickle down to residents for decades to come.”
